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A Single Centre Detailed Clinicopathological, Immunohistochemical and Follow Up Study of Male Breast Cancer Patients from Western India
3rd International Conference on Breast Pathology and Cancer Diagnosis
Vandana Nunia
Rajasthan, India
ScientificTracks Abstracts: J Clin Exp Pathol
Abstract
Aim: The clinicopathological features, Immunohistochemical (IHC) characteristics, estimated recurrence, treatment and survival outcomes of Male Breast Cancer (MBC) patients were analyzed. Methods: We have retrospectively evaluated the tumor registry data of 71 MBC (1.11% of total breast cases) patients from 2010 to 2018. Statistical analysis included the new Magee Equation 2 (nME2) for the calculation of Estimated Recurrence Score (ERS), Kaplan-Meier method to analyze survivals and cox survival model for multivariate prognostic analysis. Results: Chief complaints, history, gross and microscopic characteristic of MBC patients were investigated. MBC molecular subtypes included luminal subtype A (57.74%), luminal subtype B (26.76%), HER-2 (12.67%) and TNBC (2.81%). Male breast cancer patients were more likely to be invasive carcinoma of No Special Type (NST) (95.77%), ER positive (84.50%) PR positive (77.46%) and Her 2/Neunegative (72.97%). Low, intermediate and high estimated recurrence scores were reported in 20, 37 cases and 14 cases respectively. In the follow up study metastasis was reported in 13 cases and recurrence in 5 cases and metachronous multiple primary tumor in 2 cases. Out of 71 cases 55 were effectively followed up, 5-year Overall Survival (OS) and Disease Free Survival (DFS) rates were 72.72% and 63.63% respectively. Multivariate analysis showed lymphovascular invasion, molecular subtypes, metastasis, age, tumor size, Ki-67 and intra-ductal components to be prognostic factors for survival of MBCBiography
Vandana Nunia was under the Department of Zoology, University of Rajasthan, India
