Journal of Obesity & Weight Loss Therapy
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Cardiometabolic risk factors and epicardial adipose tissue in overweight and obese children and adolescents
International Conference on Childhood Obesity & Child Development
Schusterova I, Leenen FH, Jurko A, Tohatyova A, Takacova J and Sabol F
Eastern Heart Institute, Slovakia University of Ottawa Heart Institute, Canada P J �?聽 University, Slovakia Pediatric Cardiology Clinic, Slovakia The University of Veterinary Medicine and Pharmacy, Slovakia
Posters & Accepted Abstracts: J Obes Weight Loss Ther
DOI:
Abstract
Background: Epicardial adipose tissue (EAT) is the visceral fat deposit around the heart and is commonly increased in obese subjects. EAT is related to cardiometabolic risk factors and non-alcoholic fatty liver disease (NAFLD) in adults, but this relationship is not well known in children. Objectives: The aim of our study was to assess by echocardiography the EAT in overweight and obese children and its relationship to cardiometabolic risk factors, insulin resistance, NAFLD markers and hyperuricemia. Study Group & Methods: In 25 (mean age 13.0 �?卤 2.3) overweight and obese subjects and 24 lean controls, blood pressure (BP), WC, fasting plasma glucose and insulin, lipids, uric acid and hepatic enzymes were established and EAT thickness was measured by transthoracic echocardiography. Results: In overweight and obese subjects, EAT was significantly higher compared to normal weight children. Overweight and obese children had significantly higher body mass index (BMI), WC, BP, triglycerides (TAG), low-density lipoprotein and total cholesterol, hepatic enzymes alanine aminotransferase (ALT) and g-glutamyl transferase, and lower high-density lipoprotein cholesterol (HDL-C). EAT correlated significantly with BP, TAG, uric acid, HDL-C, apoprotein B and ALT. Correlation coefficients were similar or better than for WC, but similar or lower than for BMI. Conclusion: EAT thickness in children is associated with an unfavorable cardiometabolic risk profile including biochemical signs of NAFLD and hyperuricemia, but is not a stronger indicator than BMI.Biography
Email: petra@dodo.sk
