Alzheimer脙垄芒聜卢芒聞垄s disease (AD) is the most common form of dementia,mainly occurring in the aged population (>65 years of age).Pathologically, AD consists of two major hallmarks: neurofibrillarytangles (NFTs) and senile plaques (SPs), which are comprised of hyperphosphorylatedtau (p-tau) filaments and amyloid-脙聨脗虏 protein (A脙聨脗虏)fibrils, respectively. Numerous reports suggest that A脙聨脗虏 aggregation,namely the formation of A脙聨脗虏 oligomers, is an early event precedingother pathological changes in AD. A脙聨脗虏 is physiologically generatedfrom the cleavage of amyloid precursor protein by 脙聨脗虏- and 脙聨脗鲁-secretasesin the endoplasmic reticulum (ER) and trans-Golgi network or in thelate endosome, then secreted into the extracellular space.
Online Journals are scholarly and peer reviewed journals. The journals provide forum and motivates scientists, researchers, academics, engineers, and practitioners in all aspects to share their professional and academic knowledge in the fields computing, engineering, humanities, economics, social sciences, management, medical science, and related disciplines. Online Journals also aims to reach a large number of readers worldwide with original and current research work completed on the vital issues of the above important disciplines. The journals permit all readers to read, view, download and print the full-text of all published articles without any subscription or restrictions.
Last date updated on January, 2025