天美传媒

Lead exposure; Maternal stress; prenatal exposure; Different stage of pregnancy; Cognitive development; Birth cohort

Introduction

Both isolated and combined prenatal lead/stress exposures hampered child neurodevelopment, and the combined effects could be more severe than isolated ones [1]. Particularly in terms of socialemotional development, combined exposure during early pregnancy may lead to poorer neurodevelopmental results than combined exposure around delivery [2]. Lead exposure is a serious public health issue that can have an impact on many organs and systems [3]. There is no amount of lead exposure that is safe for humans; even modest levels of lead exposure can be dangerous over time [4]. The foetus is exposed to endogenous lead built up in the mother's body prior to pregnancy as a result of the rapid mobilisation of lead from maternal bone reserves during pregnancy [5]. And environmental exogenous lead. The foetal central nervous system is susceptible to lead exposure because of the immature blood-brain barrier, which might limit foetal brain development and lead to probable neurobehavioral dysfunctions in the future [6]. Relevant epidemiological investigations discovered a link between lead exposure during early development and behavioural and cognitive problems in later life [7]. According to animal research, lead exposure throughout adolescence may result in pathological alterations to synaptic structures that are associated to alterations in the amounts of essential synaptic proteins, which affect brain communication and synaptic transmission [8]. On the other side, individuals are experiencing mental stress at a higher rate as a result of the accelerated pace of life [9]. Pregnant women must deal with the emotional ups and downs brought on by the physiological changes associated with pregnancy as well as the mental stress brought on by the responsibilities of mothers in society or households [10].

Discussion

Prior prospective research has demonstrated that depression and anxiety during pregnancy are risk factors for unfavourable outcomes for both mothers and their offspring, including emotional, behavioural, and cognitive issues in the latter. Glover and other research on both humans and animals showed that the stimulation of the hypothalamicpituitary- adrenal axis was a mediator of these negative consequences. Considering the prenatal during a crucial time while the CNS is forming and developing, the embryo or foetus is vulnerable to environmental exposure factors. The effects of many prenatal exposures on foetal neurodevelopment must be carefully considered due to the complexity of the living environment. Although there is a lot of evidence for the cognitive effects brought on by prenatal single lead or stress exposure, realistic combination evaluation has received far less attention. In order to assess the associations between prenatal lead and stress exposures alone or in combination at various prenatal stages and offspring neurodevelopment, we used a large-scale prospective birth cohort study to examine prenatal lead and stress exposure levels in pregnant women participating in the Shanghai birth cohort study. In our hypothesis, lead exposure throughout pregnancy and Comparing stress to single exposures, the neurodevelopmental effects may be greater.

Conclusion

We also anticipated that combined exposure to lead and stress at various prenatal stages had distinct effects on offspring neurodevelopment since the reactions of embryos and foetuses (at various prenatal stages) to environmental exposures may vary. Identified standard operating procedures were utilised for the collection and handling of biological materials. Basic data on the subjects was gathered, such as prior medical histories, family histories, social environments, living conditions, diet, behaviour, physical activity, and psychological stress. Finally, 5749 couples in total who matched the inclusion criteria were sought for. A total of 3692 moms gave birth to their children, with the exception of 1622 women who had highrisk pregnancies and women who withdrew during pregnancy and had miscarriages or stillbirths. The Xinhua Hospital Institutional Review Boards, which is associated with Shanghai Jiao Tong University School of Medicine, gave its approval for this study. At the start of the trial, pregnant women were given information about the goals and methods of the study and asked to sign an appropriate informed consent form.

Acknowledgement

None

Conflict of Interest

None

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