天美传媒

Transplantation; Organ allocation; Transparent

Introduction

Organ transplantation has been a part of medical practice for over 60 years, beginning with the first successful kidney transplant in 1954. Since then, thousands of people have received organ transplants and have benefited from the procedure. However, the success of transplantation has also led to an increased demand for organs [1], particularly as the population ages and the incidence of chronic diseases increases. According to data from the United Network for Organ Sharing (UNOS), as of August 2021 [2], there were 107,987 people on the waiting list for organ transplants in the United States alone, with 87,676 waiting for kidney transplants (UNOS, 2021). Unfortunately, the number of available organs is not enough to meet this demand, and many people die while waiting for a suitable donor organ [3].

Background

One of the key ethical challenges associated with organ transplantation is the allocation of organs. The decision about who receives an organ transplant and when is complex and involves many factors, including medical urgency, compatibility, and availability of donor organs. Ethical considerations related to allocation include issues of fairness, justice, efficiency, and transparency [4]. The allocation process must be transparent and based on established criteria that are fair and just to all potential recipients.

Ethical principles

• The allocation of organs for transplantation should be guided by ethical principles which ensure that the process is fair, equitable, and transparent. The following principles are commonly used in organ allocation:

• Justice: The principle of justice requires that the allocation process treats all patients fairly regardless of their socio-economic status, race, gender, or other non-medical factors. Allocation decisions should be based solely on medical factors such as the severity of the illness and the likelihood of success in performing the transplant [5].

• Autonomy: The principle of autonomy requires that individual patients have the right to make informed decisions about their care. Patients should be informed about the risks and benefits of transplantation, and they should have the right to refuse a transplant or choose to be placed on the waiting list [6].

• Beneficence: The principle of beneficence requires that healthcare providers act in the best interests of their patients. Transplantation should be performed only when it is likely to increase the health and well-being of the patient [7].

• Non-maleficence: The principle of non-maleficence requires that healthcare providers do no harm to their patients. Transplantation should be avoided if it poses excessive risk to the recipient.

• Utility: The principle of utility requires that scarce resources be allocated in a way that maximizes overall benefit to society. Transplantation should be performed when it is likely to produce the greatest overall benefit to society [8].

Organ allocation systems

Organ allocation systems are designed to prioritize recipients based on a set of criteria that takes into account various medical and nonmedical factors. There are two main types of allocation systems:

• First-come, first-served: In this system, patients are placed on the waiting list in the order in which they apply for transplantation. This system is based on the principle of justice, which requires that patients be treated equally. However, it does not take into account the severity of the patient’s condition or the likelihood of success in performing the transplant. As a result, patients with less severe conditions may receive transplants before those with more severe conditions [9].

• Medical urgency: In this system, patients are prioritized based on the severity of their illness and the likelihood of success in performing the transplant. Patients with more severe conditions are given priority over those with less severe conditions. This system is based on the principles of beneficence and non-maleficence, which require that healthcare providers act in the best interests of their patients [10].

Conclusion

Organ transplantation is a life-saving procedure that has helped to improve the quality of life for millions of people around the world. However, the success of transplantation has also led to an increased demand for organs, creating ethical challenges for those involved in the allocation process. Ethical principles such as justice, autonomy, beneficence, non-maleficence, and utility should guide the allocation process to ensure that it is fair, equitable, and transparent. Allocation systems should prioritize patients based on the severity of their illness and the likelihood of success in performing the transplant. While there is no perfect system for allocating organs, the process can be improved

1. Swaminathan VV, Uppuluri R, Patel S, Ravichandran N, Ramanan KM, et al. (2020) . Biol Blood Marrow Transplant 26: 1326-1331.
2. Kelta M, Zekri J, Abdelghany E, Rehman JU, Khan ZA, et al. (2018) High-dose chemotherapy and peripheral hematopoietic stem cell transplantation in relapsed/refractory Hodgkin's lymphoma. Tumori. 104:471-475.

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3. Lucarelli G, Isgrò A, Sodani P, Gaziev J (2012) . Cold Spring Harb Perspect Med 2: 118-125.

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4. Ni W, Wang W, Hong J, Zhang P, Liu C (2015) A novel histopathologic finding in the Descemet's membrane of a patient with Peters Anomaly: a case-report and literature review. BMC Ophthalmol 15: 139.

, ,

5. Nischal KK, Naor J, Jay V, MacKeen LD, Rootman DS (2022) . Br J Ophthalmol 86: 62-69.

, ,

6. Datta I, Mishra S, Mohanty L, Pulikkot S, Joshi PG (2011) Neuronal plasticity of human Wharton's jelly mesenchymal stromal cells to the dopaminergic cell type compared with human bone marrow mesenchymal stromal cells. Cytotherapy 13: 918-32.

, ,

7. Germain RN (2004) . Nat Med 10: 1307-1320.

, Google Scholar,

8. Kaufmann SH (2008) Immunology's foundation: the 100-year anniversary of the Nobel Prize to Paul Ehrlich and Elie Metchnikoff. Nat Immunol 9(7):705-712

Indexed at, ,

9. Leone P, Solimando AG, Malerba E, Fasano R, Buonavoglia A, et al. (2020) . Front Oncol 10:597-598.

, ,

10. Kohler H, Pashov AD, Kieber-Emmons T (2019) Commentary: Immunology's Coming of Age. Front Immunol 10:21-75.

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