天美传媒

Abstract

Astrocytes play a crucial and complex role in the repair of axonal damage following spinal cord injury (SCI), impacting both acute and chronic phases of the condition. In the acute phase, astrocytes become activated and contribute to reactive astrogliosis, forming a glial scar that initially protects but can later impede axonal regeneration. They also release neurotrophic factors that aid in neuronal survival and modulate the inflammatory response. In the chronic phase, astrocytes continue to influence recovery through the persistent glial scar, remodeling of the extracellular matrix, and potential neurogenic activity. They also play a role in modulating synaptic plasticity. Understanding the dual nature of astrocyte functions, including their supportive and potentially obstructive roles, is essential for developing effective therapeutic strategies. This abstract highlights the potential of targeting astrocyte activity to enhance axonal repair and functional recovery in SCI, emphasizing the need for continued research to balance their beneficial and adverse effects.