天美传媒

Abstract

Cerebral hemorrhage in HIV-positive patients poses significant clinical challenges and highlights the complex interactions between HIV infection and cerebrovascular pathology. This autopsy report details a case of a 54-year-old male with HIV who suffered a fatal cerebral hemorrhage. The autopsy revealed a substantial hematoma in the left frontal lobe, accompanied by significant edema and displacement of adjacent brain tissue. Histopathological analysis showed endothelial cell injury, disruption of the blood-brain barrier, and chronic inflammation, with the presence of HIV antigens within the brain parenchyma. These findings suggest that HIV-related cerebrovascular disease, characterized by chronic inflammation and endothelial dysfunction, contributed to the hemorrhagic event. The case underscores the need for effective management of HIV to mitigate cerebrovascular risks and emphasizes the importance of early recognition and treatment of HIV-associated cerebrovascular complications.