天美传媒

Abstract

The biosynthesis of natural products and bioactive compounds plays a critical role in drug discovery, agriculture, and industrial biotechnology. These compounds, primarily sourced from plants, microbes, and marine organisms, have led to the development of many therapeutic agents, including antibiotics, anticancer drugs, and immunosuppressive agents. Recent advancements in metabolic engineering, synthetic biology, and microbial biosynthesis have revolutionized the production of bioactive compounds by enabling the design of novel biosynthetic pathways and the optimization of existing ones. This article explores the key biosynthetic pathways of natural products, such as alkaloids, terpenoids, polyketides, and peptides, and highlights emerging technologies, including genome editing, artificial intelligence, and biocatalysts, that are enhancing the efficiency and scalability of natural product production. Additionally, the potential for sustainable biosynthesis, utilizing renewable feedstock’s and reducing environmental impact, is discussed. Despite challenges in scalability and yield optimization, ongoing innovations promise to accelerate the discovery and production of high-value bioactive compounds, with significant implications for medicine, agriculture, and industrial applications.