天美传媒

Abstract

Chiral chromatography has become a cornerstone in pharmaceutical development, offering crucial advancements in the resolution and analysis of enantiomers—molecules that are mirror images of each other but differ in their biological activity and therapeutic efficacy. This technique is essential for the development of enantiomerically pure drugs, which are critical for maximizing therapeutic outcomes and minimizing side effects. Recent trends in chiral chromatography emphasize the use of novel stationary phases and advanced separation techniques to enhance resolution and throughput. Innovations such as chiral stationary phase materials, coupled with high-performance liquid chromatography (HPLC) and supercritical fluid chromatography (SFC), have expanded the capabilities of enantiomeric separation. Additionally, the integration of chiral chromatography with mass spectrometry and computational methods is streamlining the drug development process, from early-stage discovery to final formulation. These cutting-edge applications not only improve the efficiency of pharmaceutical development but also contribute to the creation of safer and more effective therapeutic agents.