天美传媒

Abstract

Liver disorders, encompassing a spectrum from viral hepatitis to non-alcoholic fatty liver disease (NAFLD) and cirrhosis, present significant global health challenges. Traditional treatment options often exhibit limitations, prompting interest in herbal medicines as alternative or adjunct therapies. This review explores the pharmacological mechanisms of herbal medicines in treating liver disorders through a comprehensive assessment and network pharmacology analysis. Herbal medicines, derived from diverse plant sources, offer a complex array of bioactive compounds with potential hepatoprotective, anti-inflammatory, antioxidant, and immunomodulatory properties. Key herbs such as Milk Thistle (Silybum marianum), Turmeric (Curcuma longa), Schisandra (Schisandra chinensis), Ginger (Zingiber officinale), and Dandelion (Taraxacum officinale) have been extensively studied for their therapeutic effects on liver function. Network pharmacology approaches elucidate intricate interactions between herbal compounds, target proteins, and biological pathways involved in liver disease pathology. Despite promising preclinical data and traditional uses, clinical evidence remains varied, highlighting challenges in standardization, safety, and regulatory oversight. Future research directions should prioritize well-designed clinical trials, molecular target elucidation, and formulation standardization to validate herbal medicines' efficacy and safety for liver disorders. This abstract underscores the potential of herbal medicines in liver disease management while emphasizing the need for rigorous scientific validation and integration into clinical practice.