天美传媒

Abstract

Next-generation sequencing (NGS) is revolutionizing the field of immunotherapy, offering unprecedented insights into the genetic and molecular landscapes of cancer and immune cells. This advanced technology enables the precise identification of genetic mutations, neoantigens, and immune-related biomarkers, which are critical for developing personalized immunotherapies. By facilitating a deeper understanding of tumor heterogeneity and the tumor microenvironment, NGS aids in the design of more effective and targeted treatments. Moreover, NGS plays a pivotal role in monitoring treatment responses and detecting minimal residual disease, thereby improving the safety and efficacy of immunotherapeutic approaches. This review explores the transformative impact of NGS on immunotherapy, highlighting its contributions to patient stratification, therapeutic targeting, and the development of novel immunotherapeutic strategies. The integration of NGS into clinical practice promises to enhance the precision of immunotherapy, ultimately leading to better patient outcomes and advancing the frontier of cancer treatment.