天美传媒

Abstract

Bongkrekic acid (BA) is a potent mitochondrial toxin produced by Burkholderia gladioli that poses severe health risks to humans upon ingestion. Its mechanism of toxicity involves inhibition of mitochondrial ATP transport, leading to metabolic acidosis and multi-organ failure. Management of BA poisoning remains challenging due to limited treatment options and rapid onset of toxicity. This case study explores the pharmacokinetics of BA and its elimination via blood purification therapies, including hemodialysis and hemoperfusion. A patient presenting with BA poisoning following ingestion of contaminated food was managed in the intensive care unit with supportive care and timely initiation of blood purification therapies. Pharmacokinetic monitoring revealed the effectiveness of these therapies in reducing BA levels and improving clinical outcomes, highlighting their role in enhancing toxin clearance. The case underscores the importance of early recognition, prompt intervention, and pharmacokinetic assessment in managing severe BA poisoning to mitigate adverse outcomes and improve patient survival.