天美传媒

Abstract

The role of host genetics in susceptibility to respiratory infections is a rapidly evolving field that reveals significant insights into how genetic variations influence individual responses to pathogens. Recent research highlights that genetic factors contribute to the variability in susceptibility, severity, and outcomes of respiratory infections such as influenza, tuberculosis, and COVID-19. Advances in genomic technologies and large-scale studies have identified specific genetic markers and pathways associated with increased risk or protection against these infections. For example, variations in genes related to immune response, inflammation, and pathogen recognition have been linked to differential disease susceptibility and progression. Understanding these genetic influences not only improves our comprehension of disease mechanisms but also opens new avenues for personalized medicine and targeted therapeutic interventions. However, challenges remain in translating genetic findings into clinical practice, including the need for further research to validate genetic associations and elucidate underlying mechanisms. Future research should focus on integrating genetic data with other omics approaches and exploring gene-environment interactions to develop more effective strategies for preventing and managing respiratory infections.