Thermodynamics of PAH with Iron, Tetrahydrobiopterin, and Phenylalanine

Name: 26th Global Obesity Meeting
Start: 2024-01-11
End: 2025-01-12
Location: Dubai, UAE

Ashraf Koura

doi:10.4172/jomb.1000224

Journal of Obesity and Metabolism
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J Obes Metab 2024, Vol 7(3): 224
DOI: 10.4172/jomb.1000224

Thermodynamics of PAH with Iron, Tetrahydrobiopterin, and Phenylalanine

Ashraf Koura^*: Department of Chemistry, Mississippi State University, USA

^*Corresponding Author : Ashraf Koura, Department of Chemistry, Mississippi State University, USA, Email: ashraf@koura.com

Received Date: Jun 01, 2024 / Published Date: Jun 30, 2024

Abstract

This study investigates the thermodynamics of phenylalanine hydroxylase (PAH) interactions with iron, tetrahydrobiopterin (BH4), and phenylalanine. Using Chromobacterium violaceum as a model, we analyze the binding affinities and thermodynamic parameters of PAH in the presence of these ligands. Our findings shed light on the energetics governing PAH activity and provide insights into the molecular mechanisms underlying phenylalanine metabolism.

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Citation: Ashraf K (2024) Thermodynamics of PAH with Iron, Tetrahydrobiopterin,and Phenylalanine. J Obes Metab 7: 224. Doi: 10.4172/jomb.1000224

Copyright: © 2024 Ashraf K. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.

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Journal of Obesity and Metabolism
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