Case Report
Application of X-ray Fluorescence Spectrometers for Biopharmaceutical Forensics
Jessica P Mondia1*, Matthew Marrichi2, Amr S Ali1, Austen Ng3 and Maureen Lanan4
1Deparment of Cell Culture Development, Biogen, Cambridge, MA 02142, USA
2Department of Manufacturing Sciences, Biogen, Cambridge, MA 02142, USA
3Department of Protein Biochemistry, Biogen, Cambridge, MA 02142, USA
4Department of Analytical and Cell Culture Development (formerly), 31 Jefferson St, Newton, MA 02458, USA
- *Corresponding Author:
- Jessica P Mondia
Deparment of Cell Culture Development, Biogen
250 Binney Street, Cambridge
MA 02142, USA
Tel: 617-679-2961
E-mail: jessica.mondia@biogen.com
Received date: September 02, 2015; Accepted date: September 22, 2015; Published date: September 29, 2015
Citation: Mondia JP, Marrichi M, Ali AS, Austen Ng, Lanan M (2015) Application of X-ray Fluorescence Spectrometers for Biopharmaceutical Forensics. J Anal Bioanal Tech 6:280. doi:10.4172/2155-9872.1000280
Copyright: © 2015 Mondia JP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
In biopharmaceutical drug development and production, a portable energy dispersive x-ray fluorescence (EDXRF) spectrometer can be used for identification of foreign particles, investigation of discolored solutions, and improvement of process understanding. The spectrometer is a safe, small, robust, rapid, easy-to-use, multielemental diagnostic tool. Examples using the EDXRF for detecting metal composition in particulates, precipitants, liquids, and resins-with rapid resolution of investigations-are described.
