Research Article
Determination of Tinidazole and Ciprofloxacin Hydrochloride in Single Formulation Tablet using Differential Pulse Polarography
Salvi V S*, Sathe P A and Rege P VDepartment of chemistry, Ramnarain Ruia College, Mumbai-400 019, India
- *Corresponding Author:
- V S Salvi
Department of chemistry
Ramnarain Ruia College
Mumbai– 400 019, India
E-mail: vaibhav.salvi27@gmail.com
Received date: October 19, 2010; Accepted date: November 24, 2010; Published date: November 26, 2010
Citation: Salvi VS, Sathe PA, Rege PV (2010) Determination of Tinidazole and Ciprofloxacin Hydrochloride in Single Formulation Tablet using Differential Pulse Polarography. J Anal Bioanal Tech 1:110. doi: 10.4172/2155-9872.1000110
Copyright: © 2010 Salvi VS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
A simple and precise method for the determination of Tinidazole and Ciprofloxacin hydrochloride from its single formulation tablet has been developed using differential pulse polarography. Tinidazole and ciprofloxacin produces a cathodic wave at -0.38 V and -1.30 V respectively versus S.C.E in a solution of pH = 6.5 (Britton Robison buffer). The dynamic range for Tinidazole, is 0.50 to 279.31μgcm -3 and for Ciprofloxacin, it is 24.39 to 245.28 μgcm -3 . The method has been validated and applied successfully for the determination of the two drugs from their respective formulation.
