Research Article
Hemocompatibility Evaluation of Polyurethane Film with Surface-Grafted Sugar- Based Amphipathic Compounds
Zhirong Xin1*, Binbin Du1, Yanming Wang1, Shengxu Qian1, Weijia Li1, Yuan Gao1, Miao Sun1, Shifang Luan2* and Jinghua Yin2
1School of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, China
2State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People’s Republic of China
- *Corresponding Author:
- Zhirong Xin
School of Chemistry and Chemical Engineering
Yantai University, Yantai 264005, China
Tel: 865356902232
Email: xinzhirong2012@126.com
Shifang Luan
State Key Laboratory of Polymer Physics and Chemistry
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
Changchun 130022, People’s Republic of China
Tel: 861068597521
E-mail: sfluan@ciac.ac.cn
Received Date: March 20, 2017; Accepted Date: April 01, 2017; Published Date: April 05, 2017
Citation: Xin Z, Du B, Wang Y, Qian S, Li W, et al. (2017) Hemocompatibility Evaluation of Polyurethane Film with Surface-Grafted Sugar-Based Amphipathic Compounds. J Anal Bioanal Tech 8:357. doi: 10.4172/2155-9872.1000357
Copyright: © 2017 Xin Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Sugar-based amphipathic compounds (BA-CnAG) were successfully prepared. Polyurethane (PU) was grafted with glycidyl methacrylate (GMA) by the means of UV irradiation, and further modified with the BA-CnAG based on the ring opening of the epoxy groups. The surface graft was confirmed by ATR-FTIR and XPS. Water contact angle, protein adsorption, and platelet adhesion measurements were used to evaluate the hydrophilicity and hemocompatibility of the films. The results demonstrated that amphiphilic surfactant-containing surfaces presented protein-resistant behavior and anti-platelet adhesion after functionalization with BA-CnAG. Besides, the hemocompatibility of the modified surface deteriorated as the length of hydrophobic chain of BA-CnAG increased.
