Research Article
Herbal Hair Gel Formulation having 5α-Reductase Inhibitory Activity and its Standardization by HPTLC
Arpan Chakraborty1, Arka Bhattacharjee2, Akshay Sodani3, Dixita Jain3, Goutam Mukhopadhyay3* and Nasim Sepay4
1Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India
2Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India
3BCDA College of Pharmacy and Technology, Kolkata, West Bengal, India
4Department of Chemistry, Presidency University, Kolkata, India
- *Corresponding Author:
- Goutam Mukhopadhyay
BCDA College of Pharmacy and Technology
Kolkata, West Bengal-700 127, India
Tel: +919836333563
E-mail: gmukhopadhyay8@gmail.com
Received date: December 17, 2016; Accepted date: December 28, 2016; Published date: December 30, 2016
Citation: Chakraborty A, Bhattacharjee A, Sodani A, Jain D, Mukhopadhyay G, et al. (2016) Herbal Hair Gel Formulation having 5 α-Reductase Inhibitory Activity and its Standardization by HPTLC. J Anal Bioanal Tech 7: 341. doi: 10.4172/2155-9872.1000341
Copyright: © 2016 Chakraborty A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The present work has been undertaken with the aim to formulate hair growth gel formulation containing extracts of Hibiscus rosa sinensis flower 1%, Eclipta alba whole plant 1% and Solanum nigrum plant berries 0.5% which are preferably used in case of Alopecia, i.e., baldness pattern as an effective therapy showing 5 α-reductase inhibitory activity. The formulated gel was evaluated for parameters such as pH which was found to be 6.68, viscosity 4731 cps, spreadability 11.05 (g-cm/sec) whereas consistent homogeneity was found with no skin irritation. Simultaneous quantification of bioactive markers was done by HPTLC. Quercetin, β-sitosterol and linoleic acid were selected as bioactive markers for quantification of Hibiscus rosa sinensis flower, Eclipta alba whole plant and Solanum nigrum plant berries extract respectively in the formulation. The aforementioned markers have 5 α-reductase inhibitory activity. β-sitosterol, quercetin and linoleic acid was found to be 0.1377, 0.120 and 0.379% w/w respectively in the formulated gel.
