Research Article
Method Development and Validation of Assay of Chlorpromazine Hydrochloride Tablet Formulation Using Ultra Violet Visible Spectrophotometry
Laila A Al Shatti*The Public Authority for Applied Education and Training, College of Nursing, Kuwait
- *Corresponding Author:
- Laila A Al Shatti
Assistant professor
The Public Authority for Applied Education and Training
College of Nursing, General Sciences Unit
P.O. Box 64923 Shuwaikh-B, 70466, State of Kuwait
Tel: 00965 22315880
Fax: 00965 24826798
E-mail: fetoon3@yahoo.com
Received date: February 18, 2014; Accepted date: March 28, 2014; Published date: March 31, 2014
Citation: Shatti LAA (2014) Method Development and Validation of Assay of Chlorpromazine Hydrochloride Tablet Formulation Using Ultra Violet Visible Spectrophotometry. J Anal Bioanal Tech 5:186. doi: 10.4172/2155-9872.1000186
Copyright: © 2014 Shatti LAA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The International Conference on Harmonisation [Q2 (R1)] guidelines was applied for this one-step spectrophotometric estimation of chlorpromazine hydrochloride in neurazine tablet formulation. The method was found to be simple, safe, sensitive, and validated for the assay of chlorpromazine hydrochloride using bromophenol blue, citrate buffer pH 3, and water as diluents. It was also found to be an accurate, reproducible, and cost-effective quality-control tool for the routine analysis of chlorpromazine hydrochloride in standard and pharmaceutical forms.
