Short Communication
Short Communication on Phototoxicity Assessment: Evaluation of Skin Phototoxicity Study Using SD Rats by Transdermal and Oral Administration
Yutaka Yonezawa1,2*, Kazuto Hashimoto1, Hiroaki Nejishima1 and Haruko Ogawa3
1Pharmacokinetics and Safety Department Drug Research Center Kaken Pharmaceutical Co., Ltd, Gensuke, Fujieda, Shizuoka 426-8646, Japan
2United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan
3Diagnostic Center for Animal Health and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, 2-11 Inada, Obihiro, Hokkaido 080 8555, Japan
- *Corresponding Author:
- Yutaka Yonezawa
Pharmacokinetics and Safety Department Drug Research Center
Kaken Pharmaceutical Co., Ltd. 301, Gensuke, Fujieda
Shizuoka 426-8646, Japan
Tel: +81 54 635 2939
Fax: +81 54 635 8940
E-mail: yonezawa_yutaka@kaken.co.jp
Received date: August 27, 2016; Accepted date: September 23, 2016; Published date: September 27, 2016
Citation: Yonezawa Y, Hashimoto K, Nejishima H, Ogawa H (2016) Short Communication on Phototoxicity Assessment: Evaluation of Skin Phototoxicity Study Using SD Rats by Transdermal and Oral Administration. Toxicol 天美传媒 Access 2:118. doi:10.4172/2476-2067.1000118
Copyright: © 2016 Yonezawa Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Guinea pigs are the most frequently used animals in phototoxicity studies. However, general toxicity studies most often use Sprague-Dawley (SD) rats. To shortening of the study period and to reduce the number of animals needed for drug development, we examined whether skin phototoxicity studies could be performed using SD rats. Drugs that had previously been shown to have phototoxic potential and known phototoxic compounds were administered transdermally and orally to guinea pigs and SD rats. After administration, the animals were irradiated with UV-A and UV-B. In the result, the concordance rate of guinea pigs and SD rats was 100% in the transdermal administration study and 85% in the oral administration study. This study demonstrated that phototoxicity studies using SD rats have the same potential to detect phototoxic compounds as studies using guinea pigs.
