Simple and Reliable Method for Characterizing in-vitro Hemoglobin Binding kinetics of Aromatic Aldehydes
*Corresponding Author:Received Date: Aug 30, 2023 / Accepted Date: Sep 01, 2023 / Published Date: Sep 29, 2023
Citation: Citation: Safo MK, Fleischman AN, Abdulmalik O (2023) Simple and Reliable Method for Characterizing in-vitro Hemoglobin Binding kinetics of Aromatic Aldehydes. J Anal Bioanal Tech S22: 004.
Copyright: Copyright: 漏 2023 Safo MK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
hematologic disorder, affecting about 20 million people worldwide. The disease arises from a single-point mutation (βGlu6 → βVal6) in the β-globin gene of Hemoglobin (Hb), resulting in sickle Hb (HbS). The primary pathophysiology of SCD involves hypoxia-induced HbS polymerization to form insoluble fibers as a result of a unique interaction between βVal6 protrusion of HbS tetramers and a hydrophobic pocket on an adjacent HbS tetramers, causing sickling of red blood cell (RBCs).
