Review Article
Targeting Hypertension to Manage Alzheimer's Disease: Rational and Promise
Cifuentes D1,2, Pasteur-Rousseau A1,3, Levy BI2, Merkulova-Rainon T2 and Kubis N1,3*
1Universite Paris Diderot, Sorbonne Paris Cite, CART, INSERM U965, F-75010 Paris, France
2Institut Vaisseaux Sang, Hopital Lariboisiere F-75010 Paris, France
3Service de Physiologie Clinique, AP-HP, Hopital Lariboisiere, F-75010 Paris, France
- Corresponding Author:
- Nathalie Kubis
Universite Paris Diderot, Sorbonne Paris Cite, CART
INSERM U965, Service de Physiologie Clinique
Hopital Lariboisiere 2 rue Ambroise Pare, 75010, Paris, France
Tel: (33) 1 49 95 88 08
E-mail: nathalie.kubis@aphp.fr
Received date: March 16, 2016; Accepted date: April 01, 2016; Published date: April 08, 2016
Citation: Cifuentes D, Pasteur-Rousseau A, Levy BI, Merkulova-Rainon T, Kubis N (2016) Targeting Hypertension to Manage Alzheimer’s Disease: Rational and Promise. J Alzheimers Dis Parkinsonism 6:228. doi:10.4172/2161-0460.1000228
Copyright: © 2016 Cifuentes D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Epidemiological, clinical and experimental animal studies uncover the close and complex interaction between Alzheimer’s disease and hypertension, a major risk factor for cardiovascular disease and stroke. Here we overview recent evidences on the impacts of both conditions on cerebral vasculature and discuss the ways in which hypertension may contribute to the onset and progression of Alzheimer’s disease.
