Research Article
With NMR Towards New Diagnostic Methods For Dengue
Camilla do Nascimento Bernardo1, Marcela Cristina Oliveira Nogueira1, Érika Pereira de Aquino1, Sina Schmidtke1, Elizandes Leal de Azeredo2, Claire Fernandes Kubelka2 and Jochen Junker1*
1Fundação Oswaldo Cruz - CDTS, Rio de Janeiro - RJ, Brazil
2Fundação Oswaldo Cruz - IOC, Rio de Janeiro - RJ, Brazil
- *Corresponding Author:
- Dr. Jochen Junker
Fundação Oswaldo Cruz - CDTS
Rio de Janeiro - RJ, Brazil
E-mail: junker@cdts.fiocruz.br
Received date: February 07, 2012; Accepted date: February 28, 2012; Published date: March 12, 2012
Citation: Bernardo CdN, Nogueira MCO, Aquino ÉPd, Schmidtke S, Azeredo ELd, et al. (2012) With NMR Towards New Diagnostic Methods For Dengue. J Anal Bioanal Tech 3:140. doi: 10.4172/2155-9872.1000140
Copyright: © 2012 Bernardo CdN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Dengue is a very common viral disease in tropical countries. From time to time it has become epidemic, hindering economics and affecting the social system. Early starting treatment reduces recovery time and suffering of the patients. But, the usual diagnostics is done by detection of the antibodies, which can only be done after five days. Other parts of the metabolomics might change much faster and therefore the small molecule content in the blood might change much faster than that. By using NMR spectroscopy we attempted to differentiate blood plasma from infected patients from healthy subjects and afterwards identify the consistent changes. Several of these were found and are discussed.
