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Journal of Cellular and Molecular Pharmacology
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Toxicokinetics And Toxicodynamics

Pharmacokinetics helps to determine the relationship between the systemic exposure of a compound in experimental animals and its toxicity. It is used in environmental risk assessments in order to determine the potential effects of releasing chemicals into the environment. It can be used to establishing relationships between exposures in toxicology experiments in animals and the corresponding exposures in humans. Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects.

Related Journals: Clinical Pharmacokinetics, Drug metabolism and pharmacokinetics, European Journal of Drug Metabolism and Pharmacokinetics, International Journal of Chemical Kinetics, Isokinetics and Exercise Science, Journal of Pharmacokinetics and Pharmacodynamics, Review of Clinical Pharmacology and Pharmacokinetics, International Edition, Cognitive Neurodynamics, Developmental Dynamics

Toxicokinetics And Toxicodynamics

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  • Tamar Ben-Bassat
    罢补尘补谤-叠别苍-叠补蝉蝉补迟-厂补尘颈-厂丑补尘辞辞苍-颁辞濒濒别驳别-辞蹿-贰苍驳颈苍别别谤颈苍驳-滨蝉谤补别濒-滨蝉谤补别濒颈-补苍诲-础尘别谤颈肠补苍-迟谤补蹿蹿颈肠-蝉颈驳苍蝉-脙垄芒聜卢芒聙聹-蝉颈尘颈濒补谤颈迟颈别蝉-诲颈蹿蹿别谤别苍肠别蝉-补苍诲-肠辞尘辫濒颈补苍肠别-飞颈迟丑-别谤驳辞苍辞尘颈肠-辫谤颈苍肠颈辫濒别蝉-辞蹿-蝉颈驳苍蝉-诲别蝉颈
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  • Kadir Genc
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    A novel synthetic antimicrobial peptide for the cure of gram-negative infections: Mechanism of action, efficacy in vivo, toxicity, bio-distribution and resistance selection
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    Investigation and molecular typing of Brucella isolated from dairy cattle herd immunized with Brucella abortus RB51 vaccine in Egypt
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    Effect of ciprofloxacin and levofloxacin alone or in combination with N-acetylcysteine on biofilm-producing Enterococcus faecalis: Contaminated root canals of extracted human teeth
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    Prevention of cognitive dysfunction and amyloid beta accumulation by the ingestion of green soybean extract in aged mice
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  • Randhawa Ramanpreet
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    Diagnosed, Identified, Current and Complete Depression Among Patients Attending Primary Care in Southern Catalonia: Different Aspects of the Same Concept
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  • Nisreen K Aref
    To compare serum leptin levels in obese women with polycystic ovary syndrome (PCOS) and normal ovulatory obese subjects in Saudi Arabia, and to evaluate the interrelationship between leptin concentration, sex hormones, and insulin resistance.
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    Women and the Healthcare Law
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    Plant biopolymers from Boraginaceae family species and their synthetic derivatives: Prospective pharmacological agents
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  • George Stoica
    Movement Disorder and Neurodegeneration in a Rat Model with Myosin 5a Mutation
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  • Khalil Khanafer
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  • Wang Bin
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  • Roberto Antonio Flores
    Control and monitoring of patients with Hypertension in the Community of the National University of Santiago del Estero, Argentina
    | PDF Version
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    Pathways and genes under positive selection in metabolic diseases
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  • Uduakobong E Ntuk
    Ethnic variation in the contribution of cardiorespiratory fitness and muscular strength to diabetes: Cross-sectional study of 68,116 UK Biobank participants
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    Salt sales survey: a simplified, cost-effective method to evaluate population salt reduction programmes-a cluster randomised trial
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    Examining the Social and Physical Environment of Adolescent Substance Users in Shanghai and East Baltimore
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    Bioprocess Development Upstream and Downstream Technologies
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  • Yosef Yarden
    Classically, the 3脙垄芒聜卢芒聞垄untranslated region (3脙垄芒聜卢芒聞垄UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3脙垄芒聜卢芒聞垄UTR alone, without all other elements in mRNA such as 5脙垄芒聜卢芒聞垄UTR and coding region. The importance of independent 3脙垄芒聜卢芒聞垄UTR RNA (referred as I3脙垄芒聜卢芒聞垄UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3脙垄芒聜卢芒聞垄UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3脙垄芒聜卢芒聞垄UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3脙垄芒聜卢芒聞垄UTR were important for its tumor suppression activity. Then, the C/EBP 3脙垄芒聜卢芒聞垄UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3脙垄芒聜卢芒聞垄UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3脙垄芒聜卢芒聞垄UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990脙垄芒聜卢芒聞垄s to 2000脙垄芒聜卢芒聞垄s, world scientists found several 3脙垄芒聜卢芒聞垄UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3脙垄芒聜卢芒聞垄UTR regions, although the existence of their transcribed products as independent 3脙垄芒聜卢芒聞垄UTR RNAs is still to be confirmed. Our studies indicate that the independent 3脙垄芒聜卢芒聞垄UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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  • Bingsong Zheng
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  • Shigeomi Horito
    Reconstruction of a transmembrane protein tetraspanin (CD9) into lipid bilayer by interaction of ganglioside GM3 and tetraspanin
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  • Veronica La Regina
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  • Kevin R. Anderson
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  • Fan-Gang Tseng
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  • Lu Jia
    Lu-Jia-Taiyuan-University-of-Science-and-Technology-China-The-research-on-technological-parameters-of-short-forming-process-of-ring-parts
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    Vascular Access Placement in Patients with Incident CKD Stage 4 and 5 attending an Inner City Nephrology Clinic: A Cohort Study and Survey of Providers
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    Shaaban-Abdallah-University-of-Cincinnati-USA-Design-and assessment-of-vertical-axis-wind-turbine-farms
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  • Yang Rongfei
    Yang-Rongfei-Nanjing-University-of-Aeronautics-and-Astronautics-China-Study-on-the-penny-platform-of-variable-stator-vane-in-compressor
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  • Gregory K. Watkins
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  • Alexander M. Wahrhaftig
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    Bee venom acupuncture in different neurological illness and its immune modulation
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    Honey as nutrient and functional food
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    Structural equation modeling of male/female handwashing behaviors during the a (H1N1) pandemic influenza in 2009-2010
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    Novel anti-retroviral drug targets: Interfering siRNA and mitochondrial TERT expression
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    Tat Oyi-based candidate therapeutic vaccine: a successful phase 1 clinical trial in HIV-1 infected patients
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    New complexes of inhaled furosemide and cyclodextrin: assessment of the bronchodilator effect
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    Translational tools as applicable to autoimmune disorders: antibody-proteases as a generation of highly informative and unique biomarkers to monitor subclinical and clinical stages of demyelination in multiple sclerosis (MS)
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    Lung neuroendocrine tumors: Correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN
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    Determinants of HIV transmission and sexual risk practices among women of childbearing age in semi-urban communities of Rivers State, Nigeria
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    Production of rosmarinic acid from in-vitro culture of Basil (Ocimum basilicum L) and lemon balm (Melissa officinalis L)
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  • David Ben-Menahem
    O-glycosylation and protein evolution: the case of the LHb to CGb development
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    Sugar-modified PPI dendrimers as carriers of anti-leukemia drugs
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    New Tools to Study and Perturb the Glycocalyx
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    N-linked Glycan Characterization and Profiling: Combining the Power of a Novel Labeling Reagent and a Streamlined Analytical Workflow
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    Fanconi anemia: Immune deficiency and susceptibility to cancer
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    Regulation of hepatic Fatty Acid Synthase properties by O-GlcNAcylation in vivo and ex vivo
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    Influence of Glycans on Biological Activities of Pituitary Gonadotropins: Follicle-Stimulating and Luteinizing Hormone
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    Manifestations of Influenza in Romania
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    Accelerating influenza research; Vaccines, antivirals, immunodulators and monoclonal antibodies. The manufacture of a new H3N2 virus for the human viral challenge model
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  • Eda Yasar
    The effect of music on the comfort and anx脙聞脗卤ety of the elderly l脙聞脗卤v脙聞脗卤ng nurs脙聞脗卤ng home
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  • Marisa Krairiksh
    Implementation of Nursing Service Strategies Supporting ASEAN Economic Community in the Year 2015 of Nursing Organizations in Thailand
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  • John D Sullivan
    Creating an oligopoly in the treatment of end stage renal disease and the subsequent impact on home hemodialysis therapies
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  • Joseph R Purita
    The use of supplements and cytokines in platelet rich plasma injections and stem cell treatments
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  • Adel Nefzi
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  • Fawad Javed
    Association between glycemic status and Oral Candida carriage in patients with prediabetes
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  • Isabelle Legastelois
    Characterization and immunogenicity in mice of rececombinant influenza haemagglutinins produced in Leishmania tarentolae
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  • Vladimir Sulimov
    脙垄芒聜卢脜聯Vladimir Sulimov-Dimonta-Ltd-and-Lomonosov-Moscow-State-University-Russia-is-it-possible-to-improve-considerably -the-accuracy-of-docking-programs脙垄芒聜卢脗聺
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  • Christain Dani
    Human Induced Pluripotent Stem cells: A new source for brown and white adipocytes
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  • Simin Fazelipour
    脙垄芒聜卢脜聯Simin Fazelipour-Islamic-Azad-University-Tehran-Medical-Sciences-Branch-Tehran-Iran-evaluation-of-histopathologic-and-histomorphometric-changes-of-adrenal-gland-tissue-following-consumption-of-Methylphenidate-in-male-mice脙垄芒聜卢脗聺
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  • Yung-Chih Kuo
    脙垄芒聜卢脜聯Yung-Chih Kuo-National-Chung-Cheng-University-Republic-of-China-Targeting-delivery-of-etoposide-to-inhibit-the-growth-of-human-glioblastoma-multiforme-using-lactoferrin-and-folic-acid-grafted-poly(lactide-co-glycolide)-nanoparticles脙垄芒聜卢脗聺
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  • Dalia Hussein Soliman
    脙垄芒聜卢脜聯Dalia Hussein Soliman-Al-Azhar-University-Egypt-Design-synthesis-docking-and-QSAR-studies-of-novel-3-5-diaryl-pyrazole-derivatives-and-their-evaluation-as-antioxidants-and-as-Immunomodulators-inhibitors-of-TNF-脙聨脗卤-IL-2-IL-6脙垄芒聜卢脗聺
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  • Justyna Trynda
    The role of microRNA-125b in calcitriol-induced differentiation of human leukemia and lymphoma cells
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