Journal of Gastrointestinal & Digestive System
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Adiponectin, Leptin, IGF1 and TNF�± serum biomarkers for non-invasive diagnosis of colorectal adenoma
9th Euro Global Gastroenterology Conference
Hassan Ashktorab, Akbar Soleimani, Hasti Olumi, Alexandra Nichols, Komal Sodhi, Laiyemo O Adeyinka, Mehdi Nouraie, Hassan Brim
Department of Medicine and Cancer Center Department of Pathology, Howard University College of Medicine, Washington DC Department of Surgery and Pharmacology and Translational Research Marshall University Joan Edwards School of Medicine, WV
Posters & Accepted Abstracts: J Gastrointest Dig Syst
DOI:
Abstract
Background and Aim: The potential role of Adiponectin, Leptin, IGF1 and TNF�± as biomarkers in colorectal adenoma is not clear. Therefore, we aimed to investigate the blood serum levels of these biomarkers in colorectal adenoma. Method: The case-control study consisted of serum from 180 African American patients with colon adenoma (cases) and 198 healthy individuals (controls) at Howard University Hospital. We used ELISA for Adiponectin, Leptin, IGF1 and TNF�± detection and quantification. Statistical analysis was performed by t-test and multivariate logistic regression. Results: The respective differences in median Leptin, Adiponectin, IGF1 and TNF�± levels between control and case groups (13.9 vs. 16.4), (11.3 vs. 46.0), (4.5 vs. 12.9) and (71.4 vs. 130.8) were statistically significant (p<0.05). In a multivariate model, the odds ratio (ORs) for Adiponectin, TNF�± and IGF1 were 2.0 (95% CI=1.6â��2.5; P<0.001), 1.5 (95% CI=1.5â�� 2.0; P 0.004) and 1.6 (95% CI=1.3â��2.0; P< 0.001), respectively. There was a positive correlation between serum Adiponectin and IGF1 concentrations with age (r=0.17, P< 0.001 and r=0.13, P=0.009), TNF�±, IGF1 and Leptin concentration with Body Mass Index (BMI) (r=0.44, P< 0.001; r=0.11, P=0.03 and r = 0.48, P<0.001), respectively. Also, there was a negative correlation between Adiponectin and Leptin concentration with BMI (r=-0.40, P<0.001 and), respectively. Conclusion: These data support the hypothesis that Adiponectin, IGF1 and TNF�± high level are increasing the risk of colon adenoma and can be applied for colorectal adenomas risk assessment.Biography
Email: hashktorab@Howard.edu
