天美传媒

ISSN: 2165-7904

Journal of Obesity & Weight Loss Therapy
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Alteration in melatonin profile associated to metabolic impairment in childhood obesity

Joint Event on 12th International Conferences on Childhood Obesity and Nutrition & 3rd World Congress on Diabetes and Obesity

Martin-Carbonell V, Gombert M, Carrasco-Luna J, Pin Arboleda and Codoner Franch P

Universidad de Valencia, SpainQuironsalud Hospital, Valencia, SpainUniversidad Catolica Valencia, SpainHospital Universitario Dr. Peset de Valencia, Spain

ScientificTracks Abstracts: J Obes Weight Loss Ther

Abstract
Introduction: Circadian rhythms are the changes in biological processes occurring on a daily base, among them, the reactions involved in the metabolic homeostasis. Melatonin is the main circadian hormone, with increased levels at night. Impairment in circadian rhythms is evidenced by altered melatonin expression, and in adult age, this condition is associated to metabolic dysregulations.

Methods: One group of obese children and a control group were constituted based on their BMI percentile for age and sex. The variations of the main circadian hormone, melatonin are assessed in saliva by immunoassay. Blood sample is collected for basal biochemistry, complemented with leptin and omentin quantification by immunoassay with Luminex technology. Life habits are assessed by self-reported questionnaires. Preliminary results on 14 patients (7 obese and 7 controls).

Results: The children from the obese group displayed poorer metabolic characteristic and increased inflammation markers: C-reactive protein, Gamma-glutamayl transferase, albumin are altered. In the control group, melatonin in saliva increased during the evening (+20.46卤16.1), whereas in the obese group, the melatonin profile was altered and globally decreased (-3.05卤28.4).

Conclusion: In conclusion obesity seems to be associated with circadian rhythm impairment even at a young age. The continuation of this study, in association with other studies investigating circadian rhythms and health during childhood will facilitate the development of life habits prevention campaigns, adapted to the children physiology and development.
Biography

Martin-Carbonell V is currently pursuing her PhD in Physiology from University of Valencia. She has completed University degree of Nutrition from Valencia University and Master degree in Pediatric Nutrition from Granada University. She has received best abstract in the International Health Days, Granada 2017. Title “Libro de Résumenes-Book of abstracts I Jornadas Internacionales de Actualización del Conocimiento Ciencias de la Salud” ISBN: 978-84-15450-26-9. She got her abstract certificate for Shorter sleep associated with higher energy intake-Preobe study in 9TM Biannual Early nutrition Project Meeting, Granada, May 2016. She has volunteered in the 42nd Annual Conference of the International Society for Pediatric and Adolescent Diabetes, Valencia in 2016.

E-mail: vanessamartin7891@gmail.com

 

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