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Abstract

The aim and objective of the study was to develop and evaluate a biodegradable polymer drug delivery system, that is capable to extend the drug release for prolonged period at predetermined rate and must be a free floating solution at room temperature which gets converted to gel with increase in temperature. In the current study 4 polymers (Poloxamer 407, Methyl cellulose, Hydroxypropyl methylcellulose and polyethylene glycol) were used alone and in combination with each other in different ratios. Pluronic PF-127 (Poloxamer 407) and methylcellulose (MC) gels below 37�ºC, at appropriate concentrations (P=18% w/v, 20% w/v, MC=4% w/v, PM=15/3% w/v, MPG 3/2 w/v and MPG 1.5/10% w/v). To evaluate the efficacy of the in-situ thermoreversible formulations in controlling the drug release, 3 drugs diclofenac sodium (hydrophobic), timolol maleate (hydrophilic) and insulin (protein) were selected. The in-situ gels were evaluated for their physical properties like Tsol-gel, viscosity, clarity of solution and gel. Based upon the in-vitro and in-vivo data, it was concluded that the system consisting of the poloxamer 407 in concentration of 20% (DP20 and TP20) are the most capable formulation for extending the drug release and maintaining therapeutic blood level of DS and TM for longer duration. The results obtained in the current study suggests that the HPLC-UV method developed is sensitive and rapid method for the determination of DS and TM in pharmaceutical preparation and physiological fluids (plasma, AH). The data also suggests that the studied polymers Poloxamer, MC and PG are good candidate to extend the drug release possessing a unique thermoreversible property.

Biography

Email: drimranwali@gmail.com