Journal of Obesity & Weight Loss Therapy
天美传媒 Access
Our Group organises 3000+ Global Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ 天美传媒 Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
天美传媒 Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Citations : 2305
Indexed In
- Index Copernicus
- Google Scholar
- 天美传媒 J Gate
- Genamics JournalSeek
- Centre for Agriculture and Biosciences International (CABI)
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- CABI full text
- Cab direct
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- University of Bristol
- Pubmed
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
Influence of high maternal leptin levels during pregnancy on metabolic characteristics of obesity-prone and obesity-resistant female offspring in mice
21st World Obesity Conference
Gonchar A,Makarova E
Novosibirsk State University, Russia Institute of Cytology and Genetics,Russia
Posters & Accepted Abstracts: J Obes Weight Loss Ther
DOI:
Abstract
Metabolic response to obesogenic diet (OD) varies widely even in mice with the same genetic background, some mice develop obesity (obesity-prone, OP), and others do not (obesity-resistant, OR). Prenatal developmental programming may impact this variability. In mice, elevated maternal leptin during pregnancy is associated with enhanced resistance to obesity in offspring but metabolic pathways affected by maternal leptin are unknown. We examined the metabolic features associated with resistance to diet-induced obesity (DIO) and the effect of hyperleptinemia during pregnancy on these characteristics in OP and OR female offspring. Females born to control C57Bl and C57Bl- Ay (hyperleptinemia during pregnancy) mothers received standard chow after weaning for 12 weeks and then they consumed OD. After eight weeks they were divided into OP or OR according to their body weight. On standard chow, OP and OR mice did not differ in food intake, but OR mice gained less weight than OP mice. Obesity development in OP mice was associated with hyperglycemia and glucose and insulin intolerance. Glucose level and insulin sensitivity were normal in OR mice and insulin receptor (InsR) mRNA expression in the liver and adipose tissue was increased compared to control (standard diet) and OP mice and it can be a mechanism providing resistance to DIO. Maternal hyperleptinemia affected only growth rate after weaning on standard diet in OR females (accelerated) and did not affect other characteristics. Perhaps, resistance to DIO may be associated with the effect of maternal leptin on the growth hormone axis in OR mice. Supported by RFBR (鈩�17-04-01357A).Biography
Gonchar A has a Bachelor's degree in Biology and is currently pursuing her Master's degree from the Faculty of Natural Sciences of the Novosibirsk State University. She took part in University and Institute of Cytology and Genetics student conferences. Her area of interest includes: diet-induced obesity, type 2 diabetes, resistance to diet-induced obesity, genetic and epigenetic mechanisms in obesity.
E-mail: alenich328@mail.ru
