天美传媒

Abstract

In this paper, new compounds synthesised during the last three and a half decades will be presented. These molecules have become intertwined with omic studies and could serve as leads for molecular medicine. Six such compound classes will be discussed here. 茂驴陆 Methoxyisoxazole quinones prepared have been shown to be potent radiosensitisers in vitro for human cancer / tumour cells, which had stopped taking up further radiation. 茂驴陆 New nitrophenyl azides prepared have been shown to exhibit inhibitory activity against Crotalaria juncea (Jute) and E . coli. In the former, these showed 茂驴陆2, 4-D茂驴陆 like activity. The corresponding amines were used to synthesise biologically interesting 9-Aryl-9H-Purine-6-amines. This work has been cited in a recent patent. 茂驴陆 5, 6- Dimethoxybenzofuroxan, which exists in two rapidly equilibrating degenerate forms has been shown to possess antifungal activity against Candida albicans and other fungi. Based on this benzofuroxan, a new indoloquinoxaline dioxide has been synthesised which could show antibacterial activity. 茂驴陆 A short synthesis of Pyrroloquinoline quinone, P. Q. Q. (Methoxatin) has been developed. This compound is considered to be a new vitamin to prevent heart attacks and strokes. 茂驴陆 New homo and hetero bifunctional crosslinkers have been developed. Similar reagents could be designed based on P.Q.Q., which will be employed for proteomics. Cholesterol /steroid photolabels are also being prepared for lipidomics. 茂驴陆 Dehydrodivanillin, a natural product has been used to prepare antifungal 1, 2, 3-triazoles using the Click reaction. In vivo and in vitro studies are being undertaken for all the above compounds to unravel the underlying biological mechanisms. This has a great potential in the area of omic studies and for developing better diagnostic tools for molecular medicine.

Biography