Breast Cancer: Current Research
天美传媒 Access
Our Group organises 3000+ Global Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ 天美传媒 Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
天美传媒 Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Citations : 114
Indexed In
- RefSeek
- Hamdard University
- EBSCO A-Z
- Publons
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
MicroRNA-145 functions as a tumor suppressor by targeting matrix metalloproteinase 11 and Rab GTPase family 27a in triple negative breast cancer
4th World Congress on Breast Pathology and Cancer Diagnosis
Feng Yan
Nanjing Medical University, China
ScientificTracks Abstracts: Breast Can Curr Res
DOI:
Abstract
Through increasing evidences have documented that microRNA-145 (miR-145) acts as a tumor suppressor in breast cancer, its exact role in triple negative breast cancer (TNBC) remains poorly defined. In this study, the expression of miR-145 in human TNBC cells and samples from 30 patients was analyzed by stem-loop real-time PCR. We found that miR-145 was significantly downregulated in TNBC tissues and cells. Upregulating miR-145 in HCC1937 cells dramatically suppressed cell proliferation and induced G1 phase arrest, whereas MDA-MB-231 cells did not show growth inhibition. MiR-145 exhibited inhibitory role in cell invasion through the post-transcriptional regulation of the novel targets MMP11 and Rab27a in TNBC cells. Additionally, miR-145 silencing could be reversed by DAC. These results demonstrated that miR-145 plays inhibitory role in TNBC malignancy by targeting MMP11 and Rab27a, which might be potential therapeutic and diagnostic targets for TNBC.Biography
Feng Yan is the Vice Director of Department of Clinical Laboratory in Nanjing Medical University Affiliated Cancer Hospital and Jiangsu Cancer Hospital. The research works focus on the Bioanalytical Chemistry in laboratory medical diagnostics, particularly in detection of tumor markers and tumor cells. She has published 42 papers in SCI journals.
