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Abstract

Resistin is an adipocyte hormone that regulates glucose metabolism. Elevated levels of resistin may cause insulin resistance. We hypothesized that tomato and broccoli extracts treatment regulates glucose homeostasis via modulation of resistin levels in high fat diet induced obesity rats (HFD). 63 male albino rats were divided into 8 groups as follows: control, HFD, stop fat diet (SD), tomato 200 mg/kg (T200), tomato 400mg/kg (T400), broccoli 200 mg/kg (B200), broccoli 400 mg/kg (B400) andchromax (CX). Treatment continued for 1 month. Serum levels of resistin, leptin, adiponectin and insulin were measured using ELISA and glucose by spectrophotometry. Serum level of resistin was significantly reduced in T 200, T 400, B 200, B 400 and CX groups to: 4.13�±0.22 ng/ml, 1.51�±0.04 ng/ml, 4.13�±0.22 ng/ml, 2.32�±0.15 ng/ml and 1.37�±0.03 ng/ml, respectively compared to HFD group and SD group (P value<0.0001). Non-significant difference was found between T 400, B 400 and CX groups. Serum level of leptin was significantly reduced in T 400 (22.7�±0.84 Pg/ml) group compared to B 400 (41�±2.45 Pg/ml) and CX groups (45.7�±2.91 Pg/ml), P value<0.001. Serum level of adiponectin was significantly increased in T 400 group (131�±3.84 Pg/ml) compared to CX group (112�±4.77 Pg/ml), P value was<0.01. Our results demonstrate that tomato and broccoli extract treatment regulates glucose homeostasis via reduction of serum resistin and may be a useful non-pharmacological therapy for obesity.

Biography

Email: naborehab@msa.eun.eg