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Abstract

Objective: Metabolic syndrome and obesity is a chronic disease that concerns over a billion people all over the world. Adipose tissue is a place of synthesis of several metabolically active proteins, called adipokines. One of such adipokines is � leptin. The aim of present study is to find correlation between leptin and risk factors of cardio-metabolic disease and androgen deficiency. Materials & Methods: The case-control study was conducted in a group of Georgian people. A total of 186 participants aged 20-70 were included for the study. The subjects who were overweight or obese were enrolled in the study group, whereas the subjects with normal weight were enrolled in the control group. The control group consisted of 20 subject with normal weight. In both groups following measurements were done: assessment of height, weight, BMI, waist circumference, blood pressure. Venus blood sample was obtained for plasma leptin, insulin, glucose and lipid profile analysis. The risk of cardio-vascular disease was calculated according the Framingham heart risk calculator. Body fat distribution was measured using Dual energy X-ray Absorbtiometer. Statistical analyses were performed using the SPSS 19.0 software package (SPSS, Inc., Chicago, IL). Results: Our study revealed that there was a correlation between serum leptin and antropometric characteristics in the whole study population, but when the population was divided into groups the correlation was lost. The positive correlation was with every region of the body in whole study population and in patients with obesity I and II degree. The correlation was not seen in patients with normal weight, over weight and morbidly obese patients. The correlation between leptin and cardio-metabolic risk factors was not detected. Conclusion: In our study Serum leptin levels are dependent mostly on body fat percentage and body fat mass. Serum leptin levels did not associate with cardio-metabolic risk factors.

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