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This paper presents a retrospective analysis of addicts treated at the Institute for addiction Zenica Doboj Canton Zenica.
Goal of the study was to determine whether the consumption of psychoactive substances has an effect on neuro-cognitive
abilities with potential influence on the development of vascular changes in the CNS and consequently the development
of dementia. The study included all patients who were hospitalized at the hospital's this medical institution. Criteria for
inclusion in the study were clinical and laboratory confirmed dependence on psychoactive substances and the absence of other
psychopathologies disorders that could affect neurocognitive abilities. Criteria for exclusion from the study were the presence
of mental illness within which occurs neurocognitive impairment. We used available data from medical records and electronic
databases for patients who met the criteria for inclusion in study. In study used standard psycho-diagnostical instruments,
Luria-Nebraska Test neurocognitive abilities, available neurophysiological (EEG) and neuro-radiologies tests (CT, MRI).
Statistical analysis was carried out in a computer program SSPS. Although efforts have been carried out statistical sample was
neither age nor sex balance. Results obtained by analyzing the data were inconsistent and mostly it was a transient impairment
of neurocognitive abilities. We could not confirm the basic hypothesis that consumption of psychoactive substances leads
to vascular changes in the blood courts and brain tissue and consequently can lead to dementia. For confirm or refute this
hypothesis will need to be more thorough and better designed studies using functional neuroimaging methods.